ACSL1 Products

Description

Long-chain-fatty-acid--CoA ligase 1, or ACSL1, is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. These proteins play an important role in lipid biosynthesis and fatty acid degradation. Like other isozymes of this family, ALCS1 converts free long-chain fatty acids into fatty acyl-CoA esters. ACSL1 preferentially uses palmitoleate, oleate and linoleate, and altered expression of ACSL1 is thought to increase accumulation of triglycerides in the liver.

ALCS1 is strongly expressed in the heart, kindey, liver, skeletal muscle, and erythroid cells, and to a lesser extent in lung, brain, placenta and pancreas. This protein is predominantly expressed during the early stages of erythroid development, and expression is weak in reticulocytes and young erythrocytes.

Bioinformatics

Entrez	14081 Mouse 2180 Human 25288 Rat
Uniprot	NP_001986 Human P33121 Human
Product By Gene ID	2180
Alternate Names	ACS1LACS 2 Acyl-CoA synthetase 1 acyl-CoA synthetase long-chain family member 1 EC 6.2.1 FACL1EC 6.2.1.3 fatty-acid-Coenzyme A ligase, long-chain 1 LACS 1 LACSlong-chain 2 lignoceroyl-CoA synthase Long-chain acyl-CoA synthetase 1 Long-chain acyl-CoA synthetase 2 Long-chain fatty acid-CoA ligase 2 long-chain fatty-acid-coenzyme A ligase 1 long-chain-fatty-acid--CoA ligase 1 Palmitoyl-CoA ligase 1 Palmitoyl-CoA ligase 2 paltimoyl-CoA ligase 1

Research Areas for ACSL1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Lipid and Metabolism
Signal Transduction

Related ACSL1 Blog Posts

Check out the latest blog posts on ACSL1.

Immune Cell Metabolic Flux Influences Type I Diabetes By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev...    Read more.

Read more ACSL1 related blogs.