APRIL/TNFSF13 Products

Description

TNFSF13 is a proliferation-inducing ligand (APRIL), also designated TNFSF13, is a Type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. APRIL is expressed in high levels in transformed cell lines and in human colon, thyroid, and lymphoid tumor tissues. APRIL is critically involved in the regulation of infections, inflammation, autoimmune diseases, and tissue homeostasis. APRIL is implicated in the regulation of tumor cell growth. The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization. The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events. Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.

Bioinformatics

Entrez	287437 Rat 69583 Mouse 8741 Human
Uniprot	AAH08042 Human NM_003808 Human NM_172088 Human NP_003799 Human O75888 Human Q8NFH7 Human
Product By Gene ID	8741
Alternate Names	A proliferation-inducing ligand APRILFLJ57090 CD256 antigen CD256 TALL2 TALL-2 TNF- and APOL-related leukocyte expressed ligand 2 TNF-related death ligand 1 TRDL-1 tumor necrosis factor (ligand) superfamily, member 13 tumor necrosis factor ligand superfamily member 13 tumor necrosis factor-like protein ZTNF2 tumor necrosis factor-related death ligand-1 ZTNF2

Research Areas for APRIL/TNFSF13

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Cycle and Replication
Cytokine Research
Immunology