E-Cadherin in Cell-Cell Adhesion and Cancer Diagnostics

Tue, 06/12/2012 - 11:05

E-Cadherin is a member of the cadherin superfamily and is fundamental player in a wide range of cellular processes such as development, morphology, polarity, migration and tissue integrity. Specifically, E-cadherin is an approximately 100 kDa epithelial cell glycoprotein whose extracellular domain interacts with that of other E-cadherin molecules on adjacent cells to establish cell-cell adhesion. This adhesion is Ca2+-dependent and a variety of interactions have been identified. E-cadherin antibodies have been extensively used in meta-analysis studies and systematic reviews to validate E-cadherin expression as a prognostic indicator and/or marker for breast cancer (infiltrating ductal and invasive lobular types) 1. A related breast cancer study found that immunohistochemistry with E-cadherin antibodies was helpful in cases of indeterminate histopathologic features2. A recent review on the role of e-Cadherin in colorectal cancer, through the use of e-Cadherin antibodies and other tools, focuses on colorectal carcinogenesis changes in the cytoskeletal network and how this new information can be used to identify therapeutic targets3. For head and neck squamous cell carcinoma, another systematic review and meta-analysis showed that aberrant expression as determined with E-cadherin antibodies, predicted poor prognosis4. The combination of E-cadherin antibody diagnostics and lymphatic vessel density are a powerful diagnostic marker for lymph node metastasis in non-small cell lung cancer5.

  1. PMID: 16791476
  2. PMID: 22558599
  3. PMID: 22176698
  4. PMID: 22455948
  5. PMID: 22528515


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