E-Cadherin as a Cancer Biomarker

Fri, 07/13/2012 - 10:59

E-cadherin is a calcium-regulated adhesion molecule expressed in most normal epithelial tissues. E-cadherin is also associated with gland formation, stratification, and epithelial polarization, while loss of E-cadherin can cause dedifferentiation and invasiveness in several human carcinomas (1). In a recent study, human breast cancer tissues were stained immunohistochemistry (IHC) by anti- E-Cadherin antibodies. Loss of E-Cadherin expression correlated with the invasiveness of carcinoma (2).

Immunohistochemistry: E-Cadherin Antibody

Similar observations were made in invasive non-lobular breast cancerous tissues by IHC using anti E-Cadherin antibodies suggesting that E-Cadherin loss may also play a role in progression and development of distant metastasis (3). In various cell lines, a reciprocal relationship has been shown between levels of E-Cadherin expression and their invasiveness as detected by E-Cadherin antibodies (4). Reduced expression of E-cadherin by IHC has been observed in several aggressive tumors supporting the notion that E-cadherin is a classic tumor suppressor gene (5).  The collective effect of E-Cadherin along with the tumor microenvironment in cancer cells may be one determinant of metastatic potential in cancer studies.

  1. PMID: 8814984
  2. PMID: 22558599
  3. PMID: 15910600
  4. PMID: 10439038
  5. PMID: 2070412

Novus Biologicals offers E-Cadherin reagents for your research needs including:


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