Blogs for July 2019

Antibody treatment can generate microglia-like cells from bone marrow

Tuesday, July 30, 2019 - 10:18
Sox2 antibody expression in induced pluripotent stem cells, ICC

By Jennifer Sokolowski, MD, PhD.

Microglia play important roles in the brain in both homeostatic and pathological conditions, acting to clear debris and dying cells. There is evidence to suggest that microglial dysfunction contributes to neurodegenerative diseases such as Alzheimer's and modulation of microglial activity may be a method to treat such diseases.1 Cell-based therapies represent a novel approach whereby the introduction of microglia that possess the desired phenotype could potentially be...

Optogenetic Control of Mitophagy: AMBRA1 based mitophagy switch

Tuesday, July 23, 2019 - 10:38
sAmbra1 expression and localization to mitochondria in human U-2 OS cell line, ICC

By Christina Towers, PhD

Mitophagy in the Brain

Selective autophagic degradation of damaged mitochondria, known as mitophagy, has been described as a cyto-protective process. Accordingly, defects in mitophagy have been associated with a number of diseases including muscle atrophy, cancer, and multiple neurodegenerative diseases. Defective mitophagy has been best described in neurons, where the accumulation of damaged mitochondria and the resulting increase in...

Deriving neural precursor cells from human induced pluripotent stem cells

Tuesday, July 16, 2019 - 14:16
Sox2 antibody expression in induced pluripotent stem cells, ICC

By Jennifer Sokolowski, MD, PhD.

Human induced pluripotent stem cells (iPSCs) can be used to create models of human organ systems and are useful for a) ascertaining the mechanisms underlying pathological conditions and b) developing and testing therapeutics. For example, studies have used iPSCs from human patients with diseases like Alzheimer's and Parkinson's to test the influence of pathological isoforms of proteins as well as the efficacy of genetic rescue.1,2

Optimized protocols to turn induced pluripotent stem cells...

Stemness is responsible for onset and metastasis of colorectal cancer

Tuesday, July 9, 2019 - 09:58
beta-Catenin expression in mouse colon, IHC

By Jamshed Arslan, Pharm. D., PhD.

Colorectal cancer stem cells are a rare subpopulation of colorectal cancer cells that can self-renew and initiate and sustain tumor growth when transplanted into an animal host.1,2 Colorectal cancer stem cells are identified by CD133, CD166, CD44, nuclear-beta-catenin, ALDH1, EphB2 and...


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