Novus Biologicals announces three new Sequestosome 1 antibodies

Novus Biologicals recently launched three new Sequestosome 1 antibodies (NBP1-42821, NBP1-42822 and NBP1-48320). These three SQSTM1 antibodies have been tested by ICC analysis on HeLa cells (view image for NBP1-42821, view image for NBP1-42822 and view image for NBP1-48320). The new SQSTM1 immunoglobulins, also known as p62 antibodies, are rabbit polyclonals and cross-react with human, mouse and rat.  NBP1-48320 also reacts with sheep, making it useful for veterinary research.

The SQSTM1 gene codes for the protein p62, an important adapter protein that serves many functions inter- and intra-cellularly. This protein binds to ubiquitin and regulates signaling pathways through ubiquitination. In particular, SQSTM1/p62 regulates the nuclear factor kappa-B (NF-kB) signaling pathway by acting as a scaffolding protein in conjunction with TNF-alpha, nerve growth factor (NGF), and interleukin-1. p62 may also contribute to titin/TTN downstream signaling in muscle cells. In May 2010, a positive feedback loop between p62 and NRF2, a transcription factor, was observed in HEK293 and p62 MEF cells by inducing antioxidant response element-driven gene transcription (Jain, et al., 2010, PMID: 20452972).

Because of its role in a myriad of signaling pathways, Sequestosome 1 may be associated with cell differentiation, apoptosis, immune response, and the regulation of potassium channels. Alternatively spliced variants with various isoforms have been identified. Mutations of the SQSTM1 gene can cause ubiquitin proteasome degradation and Paget’s disease of bone. Use the Novus Explorer to investigate other genes, pathways, and diseases that are related to SQSTM1.


For more information on these new Sequestosome 1 antibodies or to inquire about product collaborations, please contact the Novus Product Development Team by calling 303-730-1950 or via e-mail at

Release Date: 
Thursday, July 8, 2010 - 06:00