BMAL1 Products

Description

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL), also known as Bmal1 or Mop3 is a major component of the circadian clock oscillator. Specifically, BMAL-1 acts as a general dimerization partner for a subset of the bHLH-PAS (basic-helix-loop-helix-PER-ARNT-SIM) superfamily of transcription regulators, is involved in circadian rhythm generation. BMAL 1 interacts with MOP4, CLOCK, Hypoxia-inducible factor-1 alpha and -2 alpha. This interaction appears to be distinct from that of the more characterized general partner, ARNT (HIF-1Beta).

BMAL1 is highly expressed in the adult brain, skeletal muscle and heart, and has been associated with hypertension and type 2 diabetes. Because of its role in the circadian clock oscillator, BMAL-1 is also thought to be invloven seasonal affective disorder. Therefore, BMAL1 antibodies are useful for circadian studies as well as heart and brain research.

Bioinformatics

Entrez	11865 Mouse 29657 Rat 406 Human
Uniprot	AAH41129 Human NM_001030272 Human NM_001030273 Human NM_001178 Human NP_001169.3 Human O00327 Human
Product By Gene ID	406
Alternate Names	aryl hydrocarbon receptor nuclear translocator-like protein 1 aryl hydrocarbon receptor nuclear translocator-like basic-helix-loop-helix-PAS orphan MOP3 BHLHE5 bHLHe5brain and muscle bHLH-PAS protein JAP3 BMAL1TIC Brain and muscle ARNT-like 1 Class E basic helix-loop-helix protein 5 Member of PAS protein 3 member of PAS superfamily 3 MOP3BMAL1c PAS domain-containing protein 3 PASD3MGC47515

Research Areas for BMAL1

Find related products by research area and learn more about each of the different research areas below.

Cholesterol Metabolism
Chromatin Research
Circadian Rhythm
Hypoxia
Lipid and Metabolism
Neuroscience
Transcription Factors and Regulators
Vision