XPD Products

Description

The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	2068 Human
Uniprot	BC008346 Human NM_000400 Human NP_000391 Human NP_000391.1 Human NP_001124339 Human P18074 Human
Product By Gene ID	2068
Alternate Names	Basic transcription factor 2 80 kDa subunit BTF2 p80 COFS2 CXPD DNA excision repair protein ERCC-2 DNA repair protein complementing XP-D cells EC 3.6.1 EC 3.6.4.12 EM9TFIIH basal transcription factor complex 80 kDa subunit excision repair cross-complementing rodent repair deficiency, complementationgroup 2 MAG MGC102762 MGC126218 MGC126219 TFIIH 80 kDa subunit TFIIH basal transcription factor complex helicase subunit TFIIH basal transcription factor complex helicase XPD subunit TTD xeroderma pigmentosum complementary group D Xeroderma pigmentosum group D-complementing protein XPDC XPDTFIIH p80

Research Areas for XPD

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Nucleotide Excision Repair

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