Hepatitis C Virus Core Antigen Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Hepatitis C Virus Core Antigen Antibody Summary

Immunogen
Hepatitis C Virus (HCV) core protein (HCV-C1)
Specificity
Hepatitis C Virus (HCV) core protein (HCV-C1)
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HCVgp1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
Application Notes
This antibody is useful for Western Blot.

Reactivity Notes

This antibody is reactive against Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Hepatitis C Virus Core Antigen Antibody

  • Core protein p19
  • HCcAg
  • HCV core antigen
  • HCV core protein

Background

The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Hepatitis C Virus Core Antigen Antibody (NB100-93581). (Showing 1 - 2 of 2 FAQ).

  1. I have a question about HCV core protein Antibody (NB100-93581). Have you mapped the epitope? What did you use as the immunogen?
    • This antibody is a polyclonal antibody and will therefore detect multiple epitopes, none of which have been mapped. The immunogen used to raise this antibody was the purified core protein (C1) from hepatitis C virus.
  2. I saw NB100-93581's Immunogen is Hepatitis C Virus (HCV) core protein (HCV-C1). I was wondering if hepatitis C virus core antigen is amino acids 1-192 or amino acids 1-120?
    • The immunogen used to generate this antibody is residues 9-21 [CRKTKRNTNRRPQD] of the HCV core protein (C1).

Secondary Antibodies

 

Isotype Controls

Additional Hepatitis C Virus Core Antigen Products

Hepatitis C Virus Core Antigen NB100-93581

Bioinformatics Tool for Hepatitis C Virus Core Antigen Antibody (NB100-93581)

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Bioinformatics

Gene Symbol HCVgp1