DUX4 Antibody (P4H2) [DyLight 550]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC-Fr, IHC-P
Clone
P4H2
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 550

DUX4 Antibody (P4H2) [DyLight 550] Summary

Immunogen
Synthetic peptide corresponding to the C-terminus of human DUX4. [Swiss-Prot# Q9UBX2]
Localization
Nucleus. Note: Actively transported through the nuclear pore complex (NPC).
Specificity
This antibody is specific for DUX4 and does not recognize DUX4c.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
DUX4
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This DUX4 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry frozen sections, Immunohistochemistry paraffin embedded sections and Western Blot. In Western blot, a band can be seen at ~52 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for DUX4 Antibody (P4H2) [DyLight 550]

  • double homeobox 4
  • double homeobox protein 10
  • double homeobox protein 4
  • double homeobox protein 4/10
  • double homeobox protein DUX10
  • DUX10
  • DUX4
  • DUX4L1

Background

DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein. [Snider et al. (2010) PLoS Genetics.6(10): e1001181]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for DUX4 Antibody (NBP1-49552R) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP1-49552B
DyLight 350 Labeled NBP1-49552UV
DyLight 405 Labeled NBP1-49552V
DyLight 488 Labeled NBP1-49552G
DyLight 650 Labeled NBP1-49552C
DyLight 680 Labeled NBP1-49552FR
DyLight 755 Labeled NBP1-49552IR
FITC Labeled NBP1-49552F
HRP Labeled NBP1-49552H

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Bioinformatics Tool for DUX4 Antibody (NBP1-49552R)

Discover related pathways, diseases and genes to DUX4 Antibody (NBP1-49552R). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Bioinformatics

Gene Symbol DUX4
Entrez