DUX4 Products

Antibodies
Lysates
DUX4 Overexpression Lysate (N ...
DUX4 Overexpression Lysate (Native)
NBP2-05913
Applications: WB
RNAi
DUX4 RNAi
DUX4 RNAi
H00022947-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The DUX4 gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein. [Snider et al. (2010) PLoS Genetics.6(10): e1001181]

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 100288687
Alternate Names
  • double homeobox protein 4
  • double homeobox protein 4/10
  • double homeobox protein DUX10
  • double homeobox protein 10
  • DUX10
  • double homeobox 4

Research Areas for DUX4

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Transcription Factors and Regulators

Bioinformatics Tool for DUX4

Discover related pathways, diseases and genes to DUX4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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