CSN7b Antibody - Azide and BSA Free

Western Blot: CSN7b Antibody [H00064708-B01P] - Analysis of COPS7B expression in HeLa.

Immunocytochemistry/Immunofluorescence: CSN7b Antibody [H00064708-B01P] - Analysis of purified antibody to COPS7B on HeLa cell. (antibody concentration 10 ug/ml)

Western Blot: CSN7b Antibody [H00064708-B01P] - Analysis of COPS7B expression in transfected 293T cell line by COPS7B polyclonal antibody. Lane 1: COPS7B transfected lysate(29.04 KDa). Lane 2: Non-transfected lysate.

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

CSN7b Antibody - Azide and BSA Free Summary

• Immunogen: COPS7B (NP_073567.1, 1 a.a. - 264 a.a.) full-length human protein. MAGEQKPSSNLLEQFILLAKGTSGSALTALISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH
• Specificity: COPS7B - COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis),
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: COPS7B
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot 1:500
• Application Notes: Antibody reactive against recombinant protein with GST tag on ELISA and western blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for CSN7b Antibody - Azide and BSA Free

• Arabidopsis, homolog) subunit 7B
• COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
• COP9 signalosome complex subunit 7b
• CSN7BMGC111077
• FLJ12612
• Signalosome subunit 7b

Background

Component of the COP9 signalosome complex (CSN), is a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: COPS7B
• Entrez:
  • 64708(Human)
• Uniprot:
  • NP_073567.1(Human)