Niemann-Pick C1 Products

Description

Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins containing putative sterol sensing domains. The protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. NPC1 overexpression increases both the rate of trafficking of low density lipoprotein cholesterol to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma membrane. NPC disease is an inherited neurovisceral lipid storage disorder of unesterified cholesterol accumulation in lysosomes. It is characterized by progressive neural and liver degeneration, resulting from inactivating mutations in NPC1, in most cases.

Bioinformatics

Uniprot	AAH63302 Human NP_000262 Human O15118 Human
Product By Gene ID	4864
Alternate Names	FLJ98532 Niemann-Pick C1 protein Niemann-Pick disease, type C1 NPC NPC1

Research Areas for Niemann-Pick C1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cholesterol Metabolism
Lipid and Metabolism
Membrane Trafficking and Chaperones
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Neurotransmission
Signal Transduction

Related Niemann-Pick C1 Blog Posts

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NPC1: A Potential Target For Triple-Negative Breast Cancer By Natalia Gurule, PhD Breast Cancer is a Heterogeneous DiseaseBreast cancer is the most frequently identified malignancy in women, accounting for 30% of diagnosed cases of cancer in women in the US annuall...    Read more.

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