NFkB p100/p52 Products

Description

The NFkappaB transcription factor was originally identified as a protein complex consisting of a DNA binding subunit and an associated protein. The DNA binding subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino-terminus of a precursor designated p105. A cDNA has been isolated that encodes an alternative DNA binding subunit of NFkappaB. It is synthesized as a protein that is expressed in a variety of cell types and, like p105, undergoes cleavage to generate its NFkappaB subunit, in this case a protein designated p52 (previously referred to as p49). In contrast to p50 derived from p105, p52 acts in synergy with p65 to stimulate the HIV enhancer in transiently transfected Jurkat cells.

Bioinformatics

Uniprot	Q00653 Human
Product By Gene ID	4791
Alternate Names	DNA-binding factor KBF2 H2TF1 Lymphocyte translocation chromosome 10 protein Lyt10 LYT10LYT-10 nuclear factor NF-kappa-B p100 subunit nuclear factor of kappa light chain gene enhancer in B-cells 2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 Oncogene Lyt-10 p52

Research Areas for NFkB p100/p52

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Neurodegeneration
Neuroscience
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators

Related NFkB p100/p52 Blog Posts

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Nuclear Factor kappa B Signaling in the Immune System Nuclear Factor kappa B (NFkB) binds to the kappa-beta site of the immunoglobulin kappa light chain gene enhancer. Thus NFkB has become one of the widely studied transcription factors in innate and adaptive immune responses. The NFkB family is composed...    Read more.

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