NCOA6 Products

Description

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

Bioinformatics

Uniprot	Q14686 Human
Product By Gene ID	23054
Alternate Names	Activating signal cointegrator 2 AIB3NRC RAP250 Amplified in breast cancer protein 3 ASC-2 Cancer-amplified transcriptional coactivator ASC-2 KIAA0181PPAR-interacting protein NRCamplified in breast cancer-3 protein nuclear receptor coactivator 6 Nuclear receptor coactivator RAP250 Nuclear receptor-activating protein, 250 kDa peroxisome proliferator-activated receptor interacting protein PRIPPeroxisome proliferator-activated receptor-interacting protein RAP250Thyroid hormone receptor-binding protein thyroid hormone receptor binding protein TRBPASC2activating signal cointegrator-2

Research Areas for NCOA6

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
DNA Repair
Transcription Factors and Regulators
Tumor Suppressors

Related NCOA6 Blog Posts

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ASC-2: An important co-activator of different nuclear receptors ASC-2, also known as Nuclear Receptor Co-Activator 6, directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. It is involved in the co-activation of different nuclear receptors, such as for steroi...    Read more.

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