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Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.
![Western Blot Mcl-1 Antibody (542808) [Unconjugated]](http://images.novusbio.com/fullsize2/Mcl-1_MAB828_Western_Blot_6290.jpg)
![Knockout Validated Mcl-1 Antibody (542808) [Unconjugated]](http://images.novusbio.com/fullsize2/Mcl1_MAB828_Knockout_Validated_22995.jpg)
