Lactate Dehydrogenase B Products

Description

Lactate dehydrogenase (LDH) is an ubiquitous enzyme commonly found in wide variety of organisms, including plants and microbes. LDH is involved in the interconversion of the pyruvate and NADH to lactate and NAD+. It is also called Hydroxybutyrate Dehydrogenase (HBD), because it can catalyze the oxidation of hydroxybutyrate (1). In mammals, three types of LDH subunits (35 kDa) are encoded by the genes Ldh-A, Ldh-B, and Ldh-C. All LDH subunits can combine to form various terameric isoenzymes (140 kDa). Lactate dehydrogenase B (LDH-B, heart subunit, LDH-H) is involved in the conversion of L-lactate and NAD to pryruvate and NADH and it is predominantly localized in the heart tissue. Similar to other LDH subunit, LDH-B is considered to be an important marker for germ cell tumor (2).

Bioinformatics

Entrez	16832 Mouse 24534 Rat 3945 Human
Uniprot	AAH02362 Human AAH02362.1 Human NP_002291 Human P07195 Human
Product By Gene ID	3945
Alternate Names	EC 1.1.1 EC 1.1.1.27 lactate dehydrogenase B LDH heart subunit LDH-B LDH-H L-lactate dehydrogenase B chain Renal carcinoma antigen NY-REN-46 TRG-5

Research Areas for Lactate Dehydrogenase B

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HIF Target Genes
Hypoxia