GRB2 Products

Description

The growth factor bound protein 2 (GRB2) is a 25 kDa cytosolic protein that contains one src homology (SH2) domain and two SH3 domains (1). GRB2 associates with Tyrosine phosphorylated EGFRs and PDGFRs via its SH2 domain. GRB2 also plays a crucial role in two separate insulin pathways leading from the insulin receptor to the Ras protein thus affecting mitogenic signaling (2). Additionally GBR2, a bifunctional adaptor protein, recruits Sos for Ras activation and subsequent signal transmission (3).

Bioinformatics

Entrez	14784 Mouse 2885 Human 81504 Rat
Uniprot	AAH00631 Human NM_002086 Human NP_002077 Human NP_002077. Human NP_002077.1 Human P62993 Human
Product By Gene ID	2885
Alternate Names	abundant SRC homology Adapter protein GRB2 ASH EGFRBP-GRB2 epidermal growth factor receptor-binding protein GRB2 Grb3-3 growth factor receptor-bound protein 2 growth factor receptor-bound protein 3 HT027 MST084 MSTP084 NCKAP2 Protein Ash SH2/SH3 adapter GRB2

Research Areas for GRB2

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Breast Cancer
Cancer
Extracellular Matrix
Signal Transduction