GnRH Products

Description

Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle.Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.

Bioinformatics

Entrez	14715 Mouse 2796 Human
Uniprot	NP_000816 Human NP_001076580 Human
Product By Gene ID	2796
Alternate Names	GNRH GnRH-associated peptide 1 gonadotropin-releasing hormone 1 (leutinizing-releasing hormone) gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) GRH LHRH LNRH luliberin I Progonadoliberin I progonadoliberin-1 prolactin release-inhibiting factor

Research Areas for GnRH

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
GPCR

Related GnRH Blog Posts

Check out the latest blog posts on GnRH.

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