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![In vitro assay: Recombinant Mouse alpha-Synuclein Active, Monomer, (Type 1) Protein [NBP2-61595] - Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregates from the pool of active monomers. Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate is combined with 100 uM of active alpha Synuclein monomer, as compared to active alpha Synuclein aggregate and active alpha Synuclein monomer alone. Thioflavin T excitation maximum = 450 nm; emission maximum = 485 nm.](http://images.novusbio.com/fullsize/Recombinant-Mouse-alpha-Synuclein-Active-Monomer-Type-1-Protein-In-vitro-assay-NBP2-61595-img0004.jpg "In vitro assay: Recombinant Mouse alpha-Synuclein Active, Monomer, (Type 1) Protein [NBP2-61595] - Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregates from the pool of active monomers. Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate is combined with 100 uM of active alpha Synuclein monomer, as compared to active alpha Synuclein aggregate and active alpha Synuclein monomer alone. Thioflavin T excitation maximum = 450 nm; emission maximum = 485 nm.")
![In vitro assay: Recombinant Human alpha-Synuclein Active, Pre-formed Fibrils, (Type 1), A53T Mutant Protein [NBP3-14767] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures such as those in alpha synuclein fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show a limited increase in fluorescence (correlated to alpha synuclein aggregation) over time in A53T alpha synuclein monomers . A much greater increase in fluorescence is seen when 100 uM monomer is combined with 10 uM of fibrils (NBP3-14767) as the fibrils seed the formation of new fibrils from the pool of active monomers. Thioflavin T ex = 450 nm, em = 485 nm.](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Pre-formed-Fibrils-Type-1-A53T-Mutant-Protein-In-vitro-assay-NBP3-14767-img0001.jpg "In vitro assay: Recombinant Human alpha-Synuclein Active, Pre-formed Fibrils, (Type 1), A53T Mutant Protein [NBP3-14767] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures such as those in alpha synuclein fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show a limited increase in fluorescence (correlated to alpha synuclein aggregation) over time in A53T alpha synuclein monomers . A much greater increase in fluorescence is seen when 100 uM monomer is combined with 10 uM of fibrils (NBP3-14767) as the fibrils seed the formation of new fibrils from the pool of active monomers. Thioflavin T ex = 450 nm, em = 485 nm.")
![Electron Microscopy: Recombinant Human alpha-Synuclein Active, Pre-formed Fibrils, (Type 1), A53T Mutant Protein [NBP3-14767] - TEM of A53T alpha synuclein Pre-formed Fibrils (NBP3-14767)](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Pre-formed-Fibrils-Type-1-A53T-Mutant-Protein-Electron-Microscopy-NBP3-14767-img0003.jpg)
![Electron Microscopy: Recombinant Human alpha-Synuclein Active, Pre-formed Fibrils, (Type 1), A53T Mutant Protein [NBP3-14767] - TEM of A53T alpha synuclein Pre-formed Fibrils (NBP3-14767)](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Pre-formed-Fibrils-Type-1-A53T-Mutant-Protein-Electron-Microscopy-NBP3-14767-img0002.jpg)
![In vitro assay: Recombinant Human alpha-Synuclein Active, Pre-formed Fibrils, (Type 1) Acetyl (N-Term) Protein [NBP3-14769] - Thioflavin T assay for N-terminal acetylated alpha synuclein monomers and pre-formed fibrils (PFFs) (NBP3-14769). Increased fluorescence, indicative of beta-sheet formation, was seen when 50 ug N-acetylated monomer and 5 ug N-acetylated fibril were combined, compared to monomer or fibril alone.](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Pre-formed-Fibrils-Type-1-Acetyl-N-Term-Protein-In-vitro-assay-NBP3-14769-img0001.jpg "In vitro assay: Recombinant Human alpha-Synuclein Active, Pre-formed Fibrils, (Type 1) Acetyl (N-Term) Protein [NBP3-14769] - Thioflavin T assay for N-terminal acetylated alpha synuclein monomers and pre-formed fibrils (PFFs) (NBP3-14769). Increased fluorescence, indicative of beta-sheet formation, was seen when 50 ug N-acetylated monomer and 5 ug N-acetylated fibril were combined, compared to monomer or fibril alone.")
![Electron Microscopy: Recombinant Human alpha-Synuclein Active, Pre-formed Fibrils, (Type 1) Acetyl (N-Term) Protein [NBP3-14769] - TEM of N-terminal acetylated alpha synuclein pre-formed fibirls (PFFs) (NBP3-14769)](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Pre-formed-Fibrils-Type-1-Acetyl-N-Term-Protein-Electron-Microscopy-NBP3-14769-img0003.jpg)
![Electron Microscopy: Recombinant Human alpha-Synuclein Active, Pre-formed Fibrils, (Type 1) Acetyl (N-Term) Protein [NBP3-14769] - TEM of N-terminal acetylated alpha synuclein pre-formed fibirls (PFFs) (NBP3-14769)](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Pre-formed-Fibrils-Type-1-Acetyl-N-Term-Protein-Electron-Microscopy-NBP3-14769-img0002.jpg)
![In vitro assay: Recombinant Rat alpha-Synuclein Active, Pre-formed Fibrils Protein [NBP3-14774] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha synuclein monomers and fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. The Rat alpha-Synuclein monomer is very active and was able to form more beta-sheet structure alone than with the combination of monomer and fibril. In combination, the fibril (NBP3-14774) is the majority of the seed.](http://images.novusbio.com/fullsize/Recombinant-Rat-alpha-Synuclein-Active--Pre-formed-Fibrils-Protein-In-vitro-assay-NBP3-14774-img0001.jpg "In vitro assay: Recombinant Rat alpha-Synuclein Active, Pre-formed Fibrils Protein [NBP3-14774] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha synuclein monomers and fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. The Rat alpha-Synuclein monomer is very active and was able to form more beta-sheet structure alone than with the combination of monomer and fibril. In combination, the fibril (NBP3-14774) is the majority of the seed.")
![Electron Microscopy: Recombinant Rat alpha-Synuclein Active, Pre-formed Fibrils Protein [NBP3-14774] - TEM of Rat alpha-Synuclein Pre-formed Fibrils (PFFS) (NBP3-14774). 500nm](http://images.novusbio.com/fullsize/Recombinant Rat alpha-Synuclein Active- Pre-formed Fibrils Protein-Electron Microscopy-NBP3-14774-img0003.jpg)
![Electron Microscopy: Recombinant Rat alpha-Synuclein Active, Pre-formed Fibrils Protein [NBP3-14774] - TEM of Rat alpha-Synuclein Pre-formed Fibrils (PFFS) (NBP3-14774). 200nm](http://images.novusbio.com/fullsize/Recombinant-Rat-alpha-Synuclein-Active--Pre-formed-Fibrils-Protein-Electron-Microscopy-NBP3-14774-img0002.jpg)
![Immunocytochemistry/Immunofluorescence: alpha-Synuclein Antibody (AS11) [DDX0910P-100] - IF staining of human neuroblastoma (SH-SY5Y) expressing endogenous alpha-synuclein](http://images.novusbio.com/fullsize/alpha-Synuclein-Antibody-AS11-Immunocytochemistry-Immunofluorescence-DDX0910P-100-img0004.jpg "<b>Independent Antibodies Validation. </b>Immunocytochemistry/Immunofluorescence: alpha-Synuclein Antibody (AS11) [DDX0910P-100] - IF staining of human neuroblastoma (SH-SY5Y) expressing endogenous alpha-synuclein")
![<b>Independent Antibodies Validation. </b>Immunohistochemistry: alpha-Synuclein Antibody (AS11) [DDX0910P-100] - IHC staining of pathological human brains with AS11](http://images.novusbio.com/fullsize/alpha-Synuclein-Antibody-AS11-Immunohistochemistry-DDX0910P-100-img0005.jpg)
![Western Blot: Synuclein alpha/beta Antibody (9E9X5) [NBP3-33536] - Western blot analysis of lysates from U-87MG cells, using Synuclein alpha/beta Rabbit mAb at 1:1000 dilution.Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 3min.](http://images.novusbio.com/fullsize/nbp3-33536_rabbit-synuclein-alpha-beta-mab-9e9x5-1012202411353043.jpg "Western Blot: Synuclein alpha/beta Antibody (9E9X5) [NBP3-33536] - Western blot analysis of lysates from U-87MG cells, using Synuclein alpha/beta Rabbit mAb at 1:1000 dilution.Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 3min.")
![Immunocytochemistry/ Immunofluorescence: Synuclein alpha/beta Antibody (9E9X5) [NBP3-33536] - Immunofluorescence analysis of paraffin-embedded rat brain using Synuclein alpha/beta Rabbit mAb at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](http://images.novusbio.com/fullsize/nbp3-33536_rabbit-synuclein-alpha-beta-mab-9e9x5-1012202411334048.jpg)
![Western Blot: Synuclein alpha/beta Antibody (9E9X5) [NBP3-33536] - Western blot analysis of various lysates using Synuclein alpha/beta Rabbit mAb at 1:1000 dilution.Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1min.](http://images.novusbio.com/fullsize/nbp3-33536_rabbit-synuclein-alpha-beta-mab-9e9x5-101220241136068.jpg)
![SDS-Page: Recombinant Human alpha-Synuclein Active, Monomer, (Type 1) Protein [NBP2-54788] - 14kDa Human Recombinant Alpha Synuclein Protein Monomer. Lane 1: Molecular Weight Ladder (MW). Lane 2: Alpha Synuclein Protein Monomer (2 ug).](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Monomer-Type-1-Protein-SDS-Page-NBP2-54788-img0006.jpg "SDS-Page: Recombinant Human alpha-Synuclein Active, Monomer, (Type 1) Protein [NBP2-54788] - 14kDa Human Recombinant Alpha Synuclein Protein Monomer. Lane 1: Molecular Weight Ladder (MW). Lane 2: Alpha Synuclein Protein Monomer (2 ug).")
![In vitro assay: Recombinant Human alpha-Synuclein Active, Monomer, (Type 1) Protein [NBP2-54788] - Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (NBP2-54789) is combined with 100 uM of active alpha Synuclein monomer (NBP2-54788), as compared to when 100 uM of control alpha Synuclein monomer (NBP2-54786) is combined with 10 nM of active alpha Synuclein aggregate (NBP2-54789). Thioflavin T ex = 450 nm, em = 485 nm.](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Monomer-Type-1-Protein-In-vitro-assay-NBP2-54788-img0005.jpg)
![In vitro assay: Recombinant Human alpha-Synuclein Active, Monomer, (Type 2) Protein [NBP2-54786] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha synuclein fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Monomer-Type-2-Protein-In-vitro-assay-NBP2-54786-img0006.jpg "In vitro assay: Recombinant Human alpha-Synuclein Active, Monomer, (Type 2) Protein [NBP2-54786] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha synuclein fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves")
![SDS-Page: Recombinant Human alpha-Synuclein Active, Monomer, (Type 2) Protein [NBP2-54786] - SDS-PAGE of ~14 kDa Human Recombinant alpha-Synuclein Protein Monomer (NBP2-54786). Lane 1: Molecular Weight Ladder (MW). Lane 2: BSA (2.5 g). Lane 3: BSA (5 g). Lane 4: alpha-Synuclein Protein Monomer (2.5 g) (NBP2-54786). Lane 5: alpha-Synuclein Protein Monomer (5 g) (NBP2-54786).](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active-Monomer-Type-2-Protein-SDS-Page-NBP2-54786-img0007.jpg)
![Electron Microscopy: Recombinant Human alpha-Synuclein Active, Filaments Protein [NBP3-14770] - TEM of Active Human Recombinant alpha-Synuclein Protein Filaments (NBP3-14770)](http://images.novusbio.com/fullsize/Recombinant Human alpha-Synuclein Active- Filaments Protein-Electron Microscopy-NBP3-14770-img0002.jpg "Electron Microscopy: Recombinant Human alpha-Synuclein Active, Filaments Protein [NBP3-14770] - TEM of Active Human Recombinant alpha-Synuclein Protein Filaments (NBP3-14770)")
![Electron Microscopy: Recombinant Human alpha-Synuclein Active, Filaments Protein [NBP3-14770] - TEM of Active Human Recombinant alpha-Synuclein Protein Filaments (NBP3-14770)](http://images.novusbio.com/fullsize/Recombinant-Human-alpha-Synuclein-Active--Filaments-Protein-Electron-Microscopy-NBP3-14770-img0001.jpg)