4EBP1 Products

Description

4E-BP1 (eIF4E-binding protein) also known as PHAS, is a 10-12 kDa acidic protein that compete with eIF4G for binding of eiF4E to the mRNA 5' cap structure (1). Binding of the 4E-BPs to eIF4E is reversible and is dependent on the phosphorylation status of 4E-BP. Non-phosphorylated 4E-BP1 will bind strongly to eiF4E while, the phosphorylated form will no (2)t. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating 4E-BP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the 4EBP1-eIF4E interaction (3-4)

Bioinformatics

Entrez	116636 Rat 13685 Mouse 1978 Human
Uniprot	AAH04459 Human NM_004095 Human NP_004086 Human Q13541 Human
Product By Gene ID	1978
Alternate Names	4E-BP1 eIF4E-binding protein 1 eukaryotic translation initiation factor 4E binding protein 1,4EBP1,4E-BP1BP-1 eukaryotic translation initiation factor 4E-binding protein 1 PHAS-IMGC4316 Phosphorylated heat- and acid-stable protein regulated by insulin 1

Research Areas for 4EBP1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Core ESC-Like Genes
DNA Repair
DNA replication, Transcription, Translation and Splicing
Lipid and Metabolism
mTOR Pathway
Phospho-Specific
Stem Cell Markers