DRAM Products

Description

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Bioinformatics

Entrez	55332 Human 71712 Mouse 679937 Rat
Uniprot	Q8N682 Human
Product By Gene ID	55332
Alternate Names	Damage-regulated autophagy modulator DNA damage-regulated autophagy modulator protein 1 DNA-damage regulated autophagy modulator 1 DRAMFLJ11259

Research Areas for DRAM

Find related products by research area and learn more about each of the different research areas below.

Cancer