DR3/TNFRSF25 Products

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family, through their death domain containing receptors TNFR1 and Fas. A cell surface receptor with a death domain, DR3, has been identified by several groups independently, although it has been given alternative names. The ligand for DR3 has very recently been identified as TWEAK, also termed Apo3L. DR3 is highly expressed in tissues enriched in lymphocytes including PBL, thymus and spleen. DR3 mediates activation of NF kappa B, and induces apoptosis. DR3 may also play a role in regulating lymphocyte homeostasis.

Bioinformatics

Entrez	8718 Human
Uniprot	AAQ88676 Human NP_003781 Human Q93038 Human
Product By Gene ID	8718
Alternate Names	APO3 Apo-3 Apoptosis-inducing receptor AIR Apoptosis-mediating receptor DR3 Apoptosis-mediating receptor TRAMP Death receptor 3 DR3member 12 (translocatingchain-association membrane protein) Lymphocyte-associated receptor of death Protein WSL Protein WSL-1 tumor necrosis factor receptor superfamily, member 25 WSL WSL1

Research Areas for DR3/TNFRSF25

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology