Species: Hu, Mu
Applications: WB, Flow, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Bv, Ca, Ch, Eq
Applications: WB, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.
Bioinformatics
| Product By Gene ID |
397 |
| Alternate Names |
- ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
- D4
- GDIA2
- GDID4
- LYGDI
- Ly-GDI
- RAP1GN1
- RhoGDI2
|
Research Areas for D4-GDI/RhoGDI2
Find related products by research area and learn more about each of the different research areas below.
ApoptosisSignal Transduction
