Species: Hu, Mu, Rt, Rb, V-Vi, Bv, Pm-Or
Applications: WB, IP, ChIP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Goat Polyclonal
Species: Hu, Mu, Rt, Bv, Pm, Ze
Applications: IHC, IP, WB (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3'-5' DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
2071 |
| Alternate Names |
- Basic transcription factor 2 89 kDa subunit
- BTF2 p89
- BTF2
- DNA excision repair protein ERCC-3
- DNA repair protein complementing XP-B cells
- EC 3.6.1
- EC 3.6.4.12
- excision repair cross-complementing rodent repair deficiency, complementationgroup 3 (xeroderma pigmentosum group B complementing)
- GTF2H
- RAD25
- TFIIH basal transcription factor complex 89 kDa subunit
- TFIIH basal transcription factor complex helicase XPB subunit
- TFIIH p89
- TFIIH
- Xeroderma pigmentosum group B-complementing protein
- xeroderma pigmentosum, complementation group B
- XPBC
- XPBTFIIH 89 kDa subunit
|
