xCT Products

xCT Antibody
xCT Antibody
Species: Hu, Rt
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Antibody Packs
xCT Antibody Pack
xCT Antibody Pack
Species: Hu, Mu
Applications: WB, IHC
Host: Rabbit
xCT Peptide
xCT Peptide
Species: Hu
Applications: ICC/IF
xCT Peptide
xCT Peptide
Species: Hu
xCT Recombinant Protein
xCT Recombinant Protein
Species: Hu
Applications: WB, ELISA, PA
Species: Hu


xCT is a mammalian amino acid transporter. The amino acid transporter--cystine/glutamic acid transporter xCT--for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc. In the brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to enter cells.


Entrez Human
Uniprot Human
Product By Gene ID 23657
Alternate Names
  • Member 11 (Slc7a11)
  • Calcium channel blocker resistance protein CCBR1
  • cystine/glutamate transporter
  • Amino acid transport system xc-
  • xCTCCBR1
  • Solute carrier family 7 member 11
  • solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

Research Areas for xCT

Find related products by research area and learn more about each of the different research areas below.

Amino Acids, Drugs and other small molecules
Cell Biology
Lipid and Metabolism
Neuronal Cell Markers
Plasma Membrane Markers
Signal Transduction

PTMs for xCT

Learn more about PTMs related to xCT.


Bioinformatics Tool for xCT

Discover related pathways, diseases and genes to xCT. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related xCT Blog Posts

Check out the latest blog posts on xCT.
The effects of ethanol consumption on glutamate production and xCT
xCT is a sodium independent glutamate transporter that regulates the exchange of extracellular l-cystine and intracellular l-glutamate across the plasma membrane. This process is critical to glutathione production and protection from subsequent ox...    Read more.
xCT: The Membrane's Gatekeeper
xCT is an obligate, electroneutral, membrane-bound anionic transporter responsible for regulating particular amino acid gradients via their transport through plasma membrane. The antiporter xCT superficially resembles an ion channel and preferentially...    Read more.
xCT: Amino Acid Transport and Disorders of the Central Nervous System
xCT, encoded by the gene SLC7A11, is a member of the heterodimeric amino acid transporter family. Proteins within this family are linked to one another via a disulphide bond to form heterodimers consisting of one light subunit and one heavy subunit (1...    Read more.
xCT: Friend or Foe?
There are two opposing sides to the controversial cysteine/glutamate antiporter. On one hand, it can be viewed a guardian of the cell, protecting it from the damaging oxidative stress that can cause cell death and even cancer. But, conversely, it has...    Read more.
Glutathione and xCT: Chemoresistance in Tumor Cells
Glutathione, called GSH in its reduced form and GSSG or L(-)-Glutathione in its oxidized form, is an endogenous antioxidant found in most cells in the body. Glutathione's functions include detoxifying xenobiotics from the body, assisting in membrane t...    Read more.
Read more xCT related blogs.