TSC1 Products

Antibodies
TSC1 Antibody (3A2)
TSC1 Antibody (3A2)
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
TSC1 Antibody (488915)
TSC1 Antibody (488915)
MAB4379
Species: Hu
Applications: WB, CyTOF-ready, ICFlow
Host: Mouse Monoclonal
TSC1 Antibody [Unconjugated]
TSC1 Antibody [Unconjugated]
AF4379
Species: Hu, Mu, Rt
Applications: WB, CyTOF-ready, ICFlow
Host: Sheep Polyclonal
Lysates
TSC1 Overexpression Lysate (N ...
TSC1 Overexpression Lysate (Native)
NBL1-17350
Applications: WB
Proteins
Recombinant Human TSC1 Protei ...
Recombinant Human TSC1 Protein
H00007248-Q01
Species: Hu
Applications: WB, ELISA, PA
TSC1 Recombinant Protein Anti ...
TSC1 Recombinant Protein Antigen
NBP2-56378PEP
Species: Hu
Applications: AC
TSC1 Blocking Peptide
TSC1 Blocking Peptide
NBP1-76618PEP
Species: Hu
Applications: AC
RNAi
TSC1 RNAi
TSC1 RNAi
H00007248-R02
Species: Hu
Applications: RNAi, RNAi SP
TSC1 RNAi
TSC1 RNAi
H00007248-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 7248
Alternate Names
  • tumor suppressor
  • Tuberous sclerosis 1 protein
  • LAMhamartin
  • KIAA0243MGC86987
  • TSC
  • tuberous sclerosis 1

Research Areas for TSC1

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Hypoxia
mTOR Pathway
Phospho-Specific

Bioinformatics Tool for TSC1

Discover related pathways, diseases and genes to TSC1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related TSC1 Blog Posts

Check out the latest blog posts on TSC1.
TSC1 - a negative regulator of mTOR signaling
TSC1 is a tumor suppressor gene that encodes a 130 kDa protein called hamartin. TSC1 was first identified as an oncogenic driver of Tuberous Sclerosis, a condition characterized by numerous benign tumors of the skin, brain, heart, and lungs. A mut...    Read more.
Read more TSC1 related blogs.