TSC1 Products

Description

Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.

Bioinformatics

Entrez	7248 Human
Product By Gene ID	7248
Alternate Names	Hamartin KIAA0243MGC86987 LAMhamartin TSC TSC1 Tuberous sclerosis 1 protein tuberous sclerosis 1 tumor suppressor

Research Areas for TSC1

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Hypoxia
mTOR Pathway

Related TSC1 Blog Posts

Check out the latest blog posts on TSC1.

TSC1 - a negative regulator of mTOR signaling TSC1 is a tumor suppressor gene that encodes a 130 kDa protein called hamartin. TSC1 was first identified as an oncogenic driver of Tuberous Sclerosis, a condition characterized by numerous benign tumors of the skin, brain, heart, and lungs. A mut...    Read more.

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