Triosephosphate isomerase Products

Description

Triosephosphate isomerase (TIM) catalyses the reversible interconversion of G3P and DHAP. Only G3P can be used in glycolysis, therefore TIM is essential for energy production, allowing two molecules of G3P to be produced for every glucose molecule, thereby doubling the energy yield. Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.

Bioinformatics

Entrez	21991 Mouse 24849 Rat 7167 Human
Uniprot	AAH07086 Human AAH07086.1 Human NM_000365 Human NP_000356 Human P60174 Human
Product By Gene ID	7167
Alternate Names	EC 5.3.1.1 MGC88108 TIM TPI triosephosphate isomerase 1 triosephosphate isomerase Triose-phosphate isomerase

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