TRF-2 Products

Antibodies
TRF-2 Antibody
TRF-2 Antibody
NB110-57130
Species: Hu, Mu, Rt, ChHa, Pm
Applications: WB, Simple Western, ChIP, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
TRF-2 Antibody
TRF-2 Antibody
NB100-56694
Species: Hu, Mu
Applications: WB, ChIP, ICC/IF, IHC, IHC-P, IP
Host: Goat Polyclonal
Lysates
TRF-2 Overexpression Lysate ( ...
TRF-2 Overexpression Lysate (Denat...
H00007014-T01
Applications: WB
Proteins
TRF-2 Recombinant Protein
TRF-2 Recombinant Protein
H00007014-P01
Species: Hu
Applications: WB, ELISA, PA
TRF-2 Recombinant Protein Ant ...
TRF-2 Recombinant Protein Antigen
NBP1-86910PEP
Species: Hu
Applications: AC
TRF-2 Recombinant Protein Ant ...
TRF-2 Recombinant Protein Antigen
NBP1-86911PEP
Species: Hu
Applications: AC
RNAi
TRF-2 RNAi
TRF-2 RNAi
H00007014-R01
Species: Hu

Description

TRF-2 (Telomeric repeating-binding factor 2), aka TERF2 and TRBF2, is a ubiquitously expressed protein that is a component of nucleoprotein complex containing duplex 5'-TTAGGG-3' repeats. TRF-2 functions in the regulation of telomere stability. TERF2, like TERF1, contains a Myb-realted DNA binding motif and plays a key role in shield chromosome ends from degradation and end-to-end fusion, as well as preventing activation of DNA damage checkpoints. Mutant TRF-2 studies have shown that the protein is required for the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF-2 is overexpressed in a number of human tumors, so overexpression of TERF2 is thought to be oncogenic.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 7014
Alternate Names
  • Telomeric repeat binding protein 2
  • TRF2
  • TTAGGG repeat binding factor 2
  • TRF 2
  • TRBF 2
  • TERF 2
  • TERF2
  • TRBF2
  • telomeric repeat-binding factor 2
  • Telomeric DNA-binding protein
  • TTAGGG repeat-binding factor 2
  • telomeric repeat binding factor 2

Research Areas for TRF-2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Chromatin Research
Transcription Factors and Regulators
Tumor Suppressors

PTMs for TRF-2

Learn more about PTMs related to TRF-2.

Phosphorylation
Methylation
Cleavage
Acetylation
Ubiquitination

Bioinformatics Tool for TRF-2

Discover related pathways, diseases and genes to TRF-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related TRF-2 Blog Posts

Check out the latest blog posts on TRF-2.
Application Highlight: Recent uses of TERF2 in immunofluorescence (IF)
Telomeres are a region of repeat nucleotide sequences located at the end of chromosomes to protect our DNA from becoming damaged via end-to-end fusion.  TERF2, or telomeric-repeat binding factor 2, is important for telomere integrity and aids in th...    Read more.
TRF2: Telomere Maintenance and Protection
TRF2 (telomeric repeat-binding factor 2) is a homodimeric protein that binds the double-stranded 5'-TTAGGG-3' repeat in telomeres. It plays a critical role in the maintenance of telomeres, protecting telomeres against end-to-end chromosomal fusion, an...    Read more.
Read more TRF-2 related blogs.