Topoisomerase I Products

Antibodies
Topoisomerase I Antibody
Topoisomerase I Antibody
NBP1-30482
Species: Hu, Mu, Po, Bv, Ca, Eq, GP, Pm, Rb, RM
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Topoisomerase I Antibody (1A1 ...
Topoisomerase I Antibody (1A1)
H00007150-M01
Species: Hu
Applications: WB, ELISA, IHC-P
Host: Mouse Monoclonal
Topoisomerase I Antibody
Topoisomerase I Antibody
NBP1-90365
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Topoisomerase I Overexpressio ...
Topoisomerase I Overexpression Lys...
NBL1-17194
Applications: WB
Proteins
Recombinant Human Topoisomera ...
Recombinant Human Topoisomerase I ...
H00007150-Q01
Species: Hu
Applications: WB, ELISA, PA
Topoisomerase I Recombinant P ...
Topoisomerase I Recombinant Protei...
NBP1-90365PEP
Species: Hu
Applications: AC
RNAi
Topoisomerase I RNAi
Topoisomerase I RNAi
H00007150-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Topoisomerases are nuclear enzymes involved in a variety of cellular activities such as chromosome condensation, DNA replication, transcription, recombination and segregation at mitosis. Human topoisomerase I is a 100kD protein capable of relaxing positively and negatively supercoiled DNA by performing a transient single stranded nick which is then religated at the end of the reaction. It has been shown that the enzyme is located in regions of the genome that are undergoing active RNA synthesis, where it probably reduces superhelical stresses in the DNA, enabling RNA polymerase to function properly. Both DNA topoisomerases I and II have been found to be targets of autoantibodies in the sera of patients with certain autoimmune diseases such as systemic lupus erythematosus and also of some anti tumor drugs and antibiotics. Elevated levels of DNA topoisomerase I, detected by transfer assays, have been demonstrated in colorectal tumors compared with normal colon mucosa as a result of increased transcription or mRNA stability.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 7150
Alternate Names
  • type I DNA topoisomerase
  • DNA topoisomerase 1
  • TOPI
  • EC 5.99.1.2
  • DNA topoisomerase I
  • topoisomerase (DNA) I

Research Areas for Topoisomerase I

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
DNA Repair
DNA replication, Transcription, Translation and Splicing

Bioinformatics Tool for Topoisomerase I

Discover related pathways, diseases and genes to Topoisomerase I. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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