TGN38 Products

Description

The trans-Golgi network (TGN) is part of the secretory pathway of eukaryotic cells which is distinct from the Golgi stack. The TGN is important in the later stages of protein secretion where it seems to play a key role in the sorting and targeting of secreted proteins to the correct destination. Some surface receptors recycle between the cell surface and the TGN, suggesting that the TGN is also important in endocytic pathways. TGN46 cycles between the trans-Golgi network and the cell surface returning via endosomes. It is thought to be involved in regulating membrane traffic to and from trans-Golgi network. Three splice isoforms are found: TGN46, TGN48 and TGN51. Isoform TGN46 is widely expressed, isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells whilst isoform TGN51 is more abundant in fetal lung and kidney. TGN46 is a human specific protein. The rodent homologue of TGN46 is known as TGN38.

Bioinformatics

Entrez	10618 Human 22135 Mouse 192152 Rat
Uniprot	Q62314 Mouse
Product By Gene ID	10618
Alternate Names	TGN38 TGN46 TGN46TGN38 homolog TGN48MGC14722 TGN51 TGN5148, 51kD isoforms) Tgoln1 Tgoln2 trans-golgi network protein 2 Trans-Golgi network protein TGN51 Ttgn1

Research Areas for TGN38

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Cell Biology
Cellular Markers
Golgi Apparatus Markers