TDP-43/TARDBP Products

Description

TARDBP, also known as TAR DNA binding protein, is a DNA and RNA-binding protein which regulates transcription and splicing. TARDBP is also involved in the regulation of CFTR splicing and promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TARD-BP may also be involved in microRNA biogenesis, apoptosis and cell division. TARDBP can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat.

Bioinformatics

Entrez	230908 Mouse 23435 Human
Uniprot	ABO32290 Human NM_007375 Human NP_031401 Human NP_031401.1 Human Q13148 Human
Product By Gene ID	23435
Alternate Names	ALS10TAR DNA-binding protein-43 TAR DNA binding protein TDP43 TDP-43 TDP-43TAR DNA-binding protein 43

Research Areas for TDP-43/TARDBP

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Chromatin Research
DNA replication, Transcription, Translation and Splicing
Epigenetics
Immunology
microRNA
Mitochondrial Fusion Proteins
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Transcription Factors and Regulators
Virology, Bacteria and Parasites