TCF-2/HNF-1 beta Products

Description

TCF2 encodes transcription factor 2, a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.

Bioinformatics

Entrez	21410 Mouse 25640 Rat 6928 Human
Uniprot	NP_000449 Human NP_000449.1 Human NP_002948 Human P35680 Human
Product By Gene ID	6928
Alternate Names	FJHN hepatocyte nuclear factor 1-beta HNF1 beta A HNF1 homeobox B HNF-1B HNF1beta HNF-1-beta HNF2 Homeoprotein LFB3 LFB3 LF-B3 MODY5HPC11 TCF-2 TCF2transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor Transcription factor 2 transcription factor 2, hepatic Variant hepatic nuclear factor 1 vHNF1 VHNF1

Research Areas for TCF-2/HNF-1 beta

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Diabetes Research