TADA3L Products

Description

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated genetranscription by interacting functionally with the general transcription machinery bound at the basal promoter.Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, therebyrelieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activatoradaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumorsuppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least fouralternatively spliced variants have been found for this gene, but the full-length nature of some variants has not beendetermined. (provided by RefSeq)

Bioinformatics

Entrez	10474 Human
Uniprot	NP_006345 Human NP_597814.1 Human AAH13433 Human NM_006354 Human NM_133480 Human O75528 Human
Product By Gene ID	10474
Alternate Names	NGG1 Transcriptional adapter 3-like FLJ21329 transcriptional adapter 3 FLJ20221 TADA3Ltranscriptional adaptor 3 (NGG1 homolog, yeast)-like hADA3ADA3-like protein ADA3ADA3 homolog STAF54 transcriptional adaptor 3

Diseases related to TADA3L

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Malignant Neoplasms
Cell Transformation, Neoplastic
Neoplasms
Carcinoma
Papilloma
Malignant Neoplasm Of Breast
Uterine Cervical Neoplasm
Malignant Paraganglionic Neoplasm
Malignant Tumor Of Cervix
Hypokinesia
Congenital Heart Defects
Mammary Neoplasms
Genotoxic Stress
Hyperplasia
Growth Arrest

Pathways for TADA3L

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Cell Cycle
Oncogenesis
Senescence
Rna Interference
Cell Cycle Arrest
Cell Proliferation
Protein Acetylation
S Phase
Histone Acetylation
Tissue Homeostasis
Chromatin Remodeling

Research Areas for TADA3L

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Cell Cycle and Replication

PTMs for TADA3L

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Acetylation
Phosphorylation

Bioinformatics Tool for TADA3L

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