TADA3L Products

Description

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated genetranscription by interacting functionally with the general transcription machinery bound at the basal promoter.Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, therebyrelieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activatoradaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumorsuppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least fouralternatively spliced variants have been found for this gene, but the full-length nature of some variants has not beendetermined. (provided by RefSeq)

Bioinformatics

Entrez	10474 Human
Uniprot	AAH13433 Human NM_006354 Human NM_133480 Human NP_006345 Human NP_597814.1 Human O75528 Human
Product By Gene ID	10474
Alternate Names	ADA3 homolog ADA3 alteration/deficiency in activation 3 epididymis secretory sperm binding protein FLJ20221 FLJ21329 hADA3 NGG1 STAF54 TADA3L transcriptional adapter 3 Transcriptional adapter 3-like transcriptional adaptor 3

Research Areas for TADA3L

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Cell Cycle and Replication