STAT6 Products

Antibodies
STAT6 Antibody
STAT6 Antibody
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
STAT6 Antibody (SY02-72)
STAT6 Antibody (SY02-72)
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
Lysates
STAT6 Overexpression Lysate
STAT6 Overexpression Lysate
NBL1-16529
Species: Hu
Applications: WB
Proteins
Recombinant Human STAT6 GST ( ...
Recombinant Human STAT6 GST (N-Ter...
H00006778-P01
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human STAT6 GST ( ...
Recombinant Human STAT6 GST (N-Ter...
H00006778-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
STAT6 Recombinant Protein Ant ...
STAT6 Recombinant Protein Antigen
NBP1-85345PEP
Species: Hu
Applications: AC

Description

Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the Janus family tyrosine kinases (Jak)/ STAT signal transduction pathway and mediates cytokine signaling by IL 4 and IL-13 (1). STAT6 (predicted molecular weight 94kDa) has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT6 is tyrosine phosphorylated (Tyr641) in response to cellular interaction with IL-4. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 and Th9 immune response (2). Loss of STAT6 impairs IL-4 mediated functions including Th2 helper T cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. Diseases associated with STAT6 include malignant hemangiopericytoma and nut allergies.

References

1. Waqas, S. F. H., Ampem, G., & Roszer, T. (2019). Analysis of IL-4/STAT6 Signaling in Macrophages. Methods Mol Biol, 1966, 211-224. doi:10.1007/978-1-4939-9195-2_17

2. Goenka, S., & Kaplan, M. H. (2011). Transcriptional regulation by STAT6. Immunol Res, 50(1), 87-96. doi:10.1007/s12026-011-8205-2

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 6778
Alternate Names
  • STAT, interleukin-4 induced
  • signal transducer and activator of transcription 6
  • EC 2.7.7.6
  • STAT6C
  • EC 2.4.1.227
  • STAT6B
  • IL-4 Stat
  • IL-4-STAT
  • transcription factor IL-4 STAT
  • D12S1644
  • STAT, interleukin4-induced
  • signal transducer and activator of transcription 6, interleukin-4 induced

Research Areas for STAT6

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Asthma
Epitope Tags
Immunology
Phospho-Specific
Signal Transduction

Bioinformatics Tool for STAT6

Discover related pathways, diseases and genes to STAT6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related STAT6 Blog Posts

Check out the latest blog posts on STAT6.
Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation
By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.
Read more STAT6 related blogs.