Hu, Rt, Ca, PmApplications:
WB, Flow, ICC/IF, IHC, IHC-PHost:
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
Applications: WB, IP
Applications: WB, ELISA, PA, PAGE, AP
Applications: WB, ELISA, PA, AP
Stat5 is part of a 7 protein family known as signal transducer and activator of transcription (STAT) which contributes to signal transduction by cytokine, hormone and growth factor (1). Signal transducer and activator of transcription 5 (Stat5) functions both in signal transduction and activation of transcription. It has been found that cytoplasmic Stat5 is translocated to the nucleus in response to phosphorylation. Stat5 225; tyrosine phosphorylation is activated predominantly by IL2 but also by IL-3, IL-5, IL-7, IL-9, IL-15, G-CSF andGM-CSF(2). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. NCoA-1/SRC-1 acts as a coactivator for both the alpha- and beta-isoforms of Stat5 (3).
Bioinformatics Tool for STAT5A
Discover related pathways, diseases and genes to STAT5A. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.