Sphingosine Kinase 1/SPHK1 Products

Description

Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM]

Bioinformatics

Entrez	170897 Rat 20698 Mouse 8877 Human
Uniprot	AAH08040 Human NP_001136073.1 Human NP_068807 Human NP_068807. Human NP_068807.2 Human NP_892010 Human Q2M3C7 Human Q9NYA1 Human
Product By Gene ID	8877
Alternate Names	EC 2.7.1.91 sphingosine kinase 1 SPHKSK 1 SPK 1 SPK

Research Areas for Sphingosine Kinase 1/SPHK1

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism