SPARC Products

Antibodies
SPARC Antibody [Unconjugated] ...
SPARC Antibody [Unconjugated]
AF941
Species: Hu
Applications: WB, Simple Western, IHC, ICFlow
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
SPARC Antibody
SPARC Antibody
NBP1-80972
Species: Hu, Mu, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
SPARC Antibody [Unconjugated] ...
SPARC Antibody [Unconjugated]
AF942
Species: Mu
Applications: WB, IHC, ICFlow
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Lysates
SPARC Overexpression Lysate ( ...
SPARC Overexpression Lysate (Native)
NBL1-16372
Applications: WB
Proteins
Human SPARC His Protein
Human SPARC His Protein
NBP2-35270
Species: Hu
Applications: Func, PAGE
SPARC Recombinant Protein Ant ...
SPARC Recombinant Protein Antigen
NBP1-80972PEP
Species: Hu
Applications: AC
SPARC Recombinant Protein Ant ...
SPARC Recombinant Protein Antigen
NBP1-80971PEP
Species: Hu
Applications: AC
RNAi
SPARC RNAi
SPARC RNAi
H00006678-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 6678
Alternate Names
  • Osteonectin
  • Secreted protein acidic and rich in cysteine
  • osteonectin
  • Basement-membrane protein 40
  • ONcysteine-rich protein
  • BM-40
  • secreted protein, acidic, cysteine-rich (osteonectin)

Research Areas for SPARC

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication

Bioinformatics Tool for SPARC

Discover related pathways, diseases and genes to SPARC. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related SPARC Blog Posts

Check out the latest blog posts on SPARC.
Caspase 8 - a key mediator of apoptosis
Programmed cell death via apoptosis is a key controlled physiological process instigated by the cell death receptor family, their ligands, and the caspase cysteine protease family. All caspases exist in a precursor form that contains a prodomain, a...    Read more.
GAPDH: More than a housekeeping gene
GAPDH is a 146kD tetramer glycolytic pathway metabolic enzyme composed of four 30-40 kDa subunits. It is responsible for reversibly phosphorylating its substrate glyceraldehyde 3-phosphate within the glycolytic pathway.  Apart from its role in gl...    Read more.
GAPDH (Glyceraldehyde 3-Phosphate Dehydrogenase)
GAPDH is a 146 kD tetramer glycolytic pathway metabolic enzyme responsible for reversibly phosphorylating glyceraldehyde 3-phosphate. It may have other possible functions in transcriptional activation. GAPDH is highly expressed due to this housekeepin...    Read more.
FLICE, FLICE, baby
Cell death via apoptosis is a fundamental cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. All caspases exist in a precursor form compose...    Read more.
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