SOD2/Mn-SOD Products

Description

Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide (1, 2, 3). There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (CuZn SOD) and manganese-containing SOD (Mn SOD, SOD-2). The CuZn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from NFmediated apoptosis (4) via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria (6). Mn SOD has also been shown to be a tumor suppressor in human breast cancer (7). Overexpression of this enzyme protects neurons from NMDAand nitric oxide-induced neurotoxicity.

Bioinformatics

Entrez	20656 Mouse 24787 Rat 6648 Human
Uniprot	AAH12423.1 Human AAH16934 Human NM_000636 Human NM_001024465 Human NP_000627 Human NP_000627.2 Human NP_000627.2 Human NP_001019636 Human NP_001019637.1 Human P04179 Human P07895 Rat
Product By Gene ID	6648
Alternate Names	EC 1.15.1.1 indophenoloxidase B IPOB manganese-containing superoxide dismutase mangano-superoxide dismutase Mn superoxide dismutase MNSOD MVCD6 superoxide dismutase [Mn], mitochondrial superoxide dismutase 2, mitochondrial

Research Areas for SOD2/Mn-SOD

Find related products by research area and learn more about each of the different research areas below.

Cancer
Diabetes Research
Neuroscience
Tumor Suppressors