Smad2 Products

Description

Smad 2 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, nine Smads have been identified and can be divided in 3 subgroups based on their structure and functions; pathway-restricted, common mediator and inhibitory Smad. Smad 2 and 3 serve as pathway-restricted Smads for the TGF-beta/activin signaling pathways (1-2). Smad 2 is phosphorylated by the TGF-beta type 1 receptor kinase on Ser 465 and Ser 467. Phosphorylation of both serines is essential for Smad 2-Smad4 heteromeric complex and dissociation of Smad 2 from the TGF-beta type 1 receptor (3). Once phosphorylated Smad2 translocate to the nucleus where it associates with DNA-binding proteins and forming a transcriptional complex (4). Unlike Smad 3 and 4, Smad 2 does not directly bind DNA (5).

Bioinformatics

Product By Gene ID

4087

Alternate Names

hMAD-2 hSMAD2 JV18 JV18-1 JV18-1SMAD, mothers against DPP homolog 2 (Drosophila) MAD homolog 2 Mad protein homolog Mad, mothers against decapentaplegic homolog 2 MADH2 MADH2MGC34440 MADR2 MADR2MGC22139 Mad-related protein 2 mother against DPP homolog 2 mothers against decapentaplegic homolog 2 Mothers against DPP homolog 2 Sma- and Mad-related protein 2 SMAD 2 SMAD family member 2MAD, mothers against decapentaplegic homolog 2 (Drosophila) SMAD, mothers against DPP homolog 2 Smad2 Smox

Research Areas for Smad2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Metastasis
Stem Cell Signaling Pathway
Wnt Signaling Pathway

Related Smad2 Blog Posts

Check out the latest blog posts on Smad2.

TGF-beta for treating degenerative intervertebral disc disease By Jamshed Arslan Pharm.D. Our upright posture and balance depend on a jelly-like material, called nucleus pulposus (NP), in the middle of intervertebral discs. NP cells protect us from disc degeneration by maintain...    Read more.

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