SLP-76/LCP2 Products

Description

SLP76 (SH2 domain containing leukocyte protein of 76 kDa) is a hematopoietic cell-specific adaptor protein that is crucial for T-cell receptor (TCR) signaling, hemostasis and platelet function. TCR ligation and fibrinogen binding to integrin alpha 2 beta 3 stimulates the phosphorylation of the tyrosine residues in the amino terminus, and facilitates SLP76 binding to the SH2 domain of Vav, which can activate JNK. SLP76 also comprises a proline-rich domain region that associates with the SH3 domain of Grb2 linking SLP76 to the Ras to Raf to ERK1 & 2 signaling pathway, LAT, PLC gamma, Fyn-binding protein (SLAP130), the SH2 containing phosphatase 1 and Nck, which mediates the regulation of cytoskeletal actin polymerization. Phosphorylation of tyrosine 145 has been shown to be important for optimal SLP76 function.

Bioinformatics

Entrez	16822 Mouse 3937 Human
Uniprot	AAH16618 Human AAH16618.1 Human NM_005565 Human NP_005556 Human NP_005556. Human Q13094 Human
Product By Gene ID	3937
Alternate Names	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of76kDa) lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of76kD) lymphocyte cytosolic protein 2 SH2 domain-containing leukocyte protein of 76 kDa SH2 domain-containing leukocyte protein of 76kD SLP-76 tyrosine phosphoprotein SLP-76 SLP7676 kDa tyrosine phosphoprotein

Research Areas for SLP-76/LCP2

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction