SLP-76/LCP2 Products

Description

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq]

Bioinformatics

Entrez	3937 Human
Uniprot	AAH16618.1 Human
Product By Gene ID	3937
Alternate Names	LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of76kDa) lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of76kD) lymphocyte cytosolic protein 2 SH2 domain-containing leukocyte protein of 76 kDa SH2 domain-containing leukocyte protein of 76kD SLP-76 tyrosine phosphoprotein SLP76 SLP-76 SLP7676 kDa tyrosine phosphoprotein

Research Areas for SLP-76/LCP2

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Signal Transduction