SLP-76/LCP2 Products

Antibodies
SLP-76/LCP2 [p Tyr145] Antibo ...
SLP-76/LCP2 [p Tyr145] Antibody (7...
MAB7474
Species: Hu
Applications: WB, Simple Western, ICC
Host: Mouse Monoclonal
SLP-76/LCP2 Antibody (460004) ...
SLP-76/LCP2 Antibody (460004)
MAB5637
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Lysates
SLP-76/LCP2 Overexpression Ly ...
SLP-76/LCP2 Overexpression Lysate ...
H00003937-T01
Species: Hu
Applications: WB
SLP-76/LCP2 Overexpression Ly ...
SLP-76/LCP2 Overexpression Lysate ...
NBL1-12467
Applications: WB
Proteins
SLP-76/LCP2 Recombinant Prote ...
SLP-76/LCP2 Recombinant Protein
H00003937-P01
Species: Hu
Applications: WB, ELISA, PA
SLP-76/LCP2 Recombinant Prote ...
SLP-76/LCP2 Recombinant Protein
H00003937-P02
Species: Hu
Applications: WB, ELISA, PA
SLP-76/LCP2 Recombinant Prote ...
SLP-76/LCP2 Recombinant Protein An...
NBP1-87033PEP
Species: Hu
Applications: AC

Description

SLP76 (SH2 domain containing leukocyte protein of 76 kDa) is a hematopoietic cell-specific adaptor protein that is crucial for T-cell receptor (TCR) signaling, hemostasis and platelet function. TCR ligation and fibrinogen binding to integrin alpha 2 beta 3 stimulates the phosphorylation of the tyrosine residues in the amino terminus, and facilitates SLP76 binding to the SH2 domain of Vav, which can activate JNK. SLP76 also comprises a proline-rich domain region that associates with the SH3 domain of Grb2 linking SLP76 to the Ras to Raf to ERK1 & 2 signaling pathway, LAT, PLC gamma, Fyn-binding protein (SLAP130), the SH2 containing phosphatase 1 and Nck, which mediates the regulation of cytoskeletal actin polymerization. Phosphorylation of tyrosine 145 has been shown to be important for optimal SLP76 function.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 3937
Alternate Names
  • SLP-76 tyrosine phosphoprotein
  • SH2 domain-containing leukocyte protein of 76kD
  • SH2 domain-containing leukocyte protein of 76 kDa
  • lymphocyte cytosolic protein 2
  • SLP-76
  • SLP7676 kDa tyrosine phosphoprotein
  • lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of76kD)
  • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of76kDa)

Research Areas for SLP-76/LCP2

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction

Bioinformatics Tool for SLP-76/LCP2

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