Separase Products

Antibodies
Separase Antibody (XJ11-4D7)
Separase Antibody (XJ11-4D7)
NB100-330
Species: Hu
Applications: ICC/IF
Host: Mouse Monoclonal
Separase Antibody (6H6)
Separase Antibody (6H6)
H00009700-M01
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
Proteins
Separase Peptide
Separase Peptide
BC110-55296PEP
Species: Hu
Separase Peptide
Separase Peptide
BC110-55295PEP
Species: Hu
Separase Partial Recombinant ...
Separase Partial Recombinant Protein
H00009700-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Separase RNAi
Separase RNAi
H00009700-R01
Species: Hu

Description

Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase, but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers. Separase antibodies can be used as a specific marker for centrosomes of mitotic cells. The staining of separase in centrosomes can be detected from prophase of mitosis up until anaphase.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Product By Gene ID 9700
Alternate Names
  • extra spindle poles like 1 (S. cerevisiae)
  • Separase
  • Extra spindle poles-like 1 protein
  • EC 3.4.22.49
  • Caspase-like protein ESPL1
  • KIAA0165separin
  • ESP1extra spindle poles like 1
  • FLJ46492
  • extra spindle pole bodies homolog 1 (S. cerevisiae)

Research Areas for Separase

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cell Cycle and Replication
Cellular Markers
Chromatin Research
DNA Repair
Mitotic Regulators
Phospho-Specific

PTMs for Separase

Learn more about PTMs related to Separase.

Cleavage

Bioinformatics Tool for Separase

Discover related pathways, diseases and genes to Separase. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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