SART1 Products

Description

SART1, also known as hypoxia-associated factor (HAF), encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq]

Bioinformatics

Entrez	20227 Mouse 29678 Rat 9092 Human
Uniprot	NP_005137 Human NP_005137. Human NP_005137.1 Human O43290 Human Q9Z315 Mouse
Product By Gene ID	9092
Alternate Names	Allergen Hom s 1 Ara1 HAF HOMS1 hSART-1 hSnu66 hypoxia-associated factor IgE autoantigen MGC2038 SART-1 SART1(259) protein SART1(800) protein SART1259 small nuclear ribonucleoprotein 110kDa (U4/U6.U5) SNRNP110 SNU66 homolog Snu66 squamous cell carcinoma antigen recognised by T cells Squamous cell carcinoma antigen recognized by T cells 1 squamous cell carcinoma antigen recognized by T cells U4/U6.U5 tri-snRNP-associated 110 kDa protein U4/U6.U5 tri-snRNP-associated protein 1

Research Areas for SART1

Find related products by research area and learn more about each of the different research areas below.

Hypoxia