ROCK1 Products

Antibodies
ROCK1 Antibody
ROCK1 Antibody
NB100-624
Species: Hu, Mu, Primate, Rabbit, Rat, Monkey
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
ROCK1 Antibody (701118)
ROCK1 Antibody (701118)
MAB4590
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
ROCK1 Antibody
ROCK1 Antibody
NBP1-82450
Species: Hu, Mu, Rt, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
ROCK1 Overexpression Lysate ( ...
ROCK1 Overexpression Lysate (Native)
NBP2-07756
Applications: WB
Proteins
ROCK1 Partial Recombinant Pro ...
ROCK1 Partial Recombinant Protein
H00006093-Q01
Species: Hu
Applications: WB, ELISA, PA
ROCK1 Recombinant Protein Ant ...
ROCK1 Recombinant Protein Antigen
NBP2-13244PEP
Species: Hu
Applications: AC
ROCK1 Recombinant Protein Ant ...
ROCK1 Recombinant Protein Antigen
NBP1-82450PEP
Species: Hu
Applications: AC
RNAi
ROCK1 RNAi
ROCK1 RNAi
H00006093-R03
Species: Hu

Description

Rho-associated kinase I (ROCK1, ROK beta, p160ROCK) is a serine-threonine protein kinase and an effector of the small GTPase Rho. With N-terminus protein kinase domain and C-terminus Rho-binding domain/pleckstrin homology domain, ROCK1 can be activated by either RhoA or RhoB. In Rho specific ROCK1 activation, a Rho protein binds to the Rho-binding domain and induces a conformational change which opens the kinase domain for the phosphorylation of downstream effectors (1). Activated ROCK1 phosphorylates various signaling proteins, such as myosin light chain phosphatase, LIM kinases, and ezrin-radixin-moesin proteins. Caspase-3 also activates ROCK1; Caspase-3 cleaves ROCK1 at DETD1113/G sequence and removes its inhibitory c-terminal domain. This activation, independent of Rho activity, leads to apoptotic membrane blebbing (2). ROCK1 is involved in regulating actin cytoskeleton assembly, cell migration, centromere positing, smooth muscle contraction, and neurite outgrowth. Its involvement in tumor invasion, hypertension, and bronchial asthma makes ROCK1 an ideal target for drug development (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 6093
Alternate Names
  • EC 2.7.11
  • MGC131603
  • rho-associated protein kinase 1
  • EC 2.7.11.1
  • Rho kinase
  • p160 ROCK-1
  • p160-ROCK
  • Rho-associated, coiled-coil-containing protein kinase 1
  • PRO0435
  • Renal carcinoma antigen NY-REN-35
  • P160ROCK
  • p160ROCK
  • MGC43611
  • Rho-associated, coiled-coil containing protein kinase 1

Research Areas for ROCK1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Signal Transduction
Wnt Signaling Pathway

Bioinformatics Tool for ROCK1

Discover related pathways, diseases and genes to ROCK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ROCK1 Blog Posts

Check out the latest blog posts on ROCK1.
A good helper on validating your FLOW and IHC data - Rabbit IgG Isotype Control
Isotype controls are primarily used as negative controls in flow cytometry but they can also be used for immunohistochemistry. They are used to approximate the non-specific target primary antibody binding due to protein-protein interactions, binding t...    Read more.
Read more ROCK1 related blogs.