ROBO1 Products

Description

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. In Drosophila, the roundabout gene, a member of the immunoglobulin gene superfamily, encodes an integral membrane protein that is both an axon guidance receptor and a cell adhesion receptor. This receptor is involved in the decision by axons to cross the central nervous system midline. The protein encoded by this gene is structurally similar to the Drosophila roundabout protein. Two transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	19876 Mouse 58946 Rat 6091 Human
Uniprot	NP_002932 Human NP_002932.1 Human NP_062286.2 Mouse NP_598334 Human Q9Y6N7 Human
Product By Gene ID	6091
Alternate Names	DUTT1Drosophila) homolog 1 H-Robo-1 MGC131599 MGC133277 roundabout, axon guidance receptor, homolog 1 (Drosophila)

Research Areas for ROBO1

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Angiogenesis
Cancer
Extracellular Matrix