RFXAP Products

Antibodies
RFXAP Antibody
RFXAP Antibody
H00005994-D01P
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
RFXAP Antibody
RFXAP Antibody
NBP2-58217
Species: Hu, Mu, Rt
Applications: ICC/IF
Host: Rabbit Polyclonal
RFXAP Antibody (1B5)
RFXAP Antibody (1B5)
H00005994-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
RFXAP Overexpression Lysate ( ...
RFXAP Overexpression Lysate (Denat...
H00005994-T02
Species: Hu
Applications: WB
RFXAP Overexpression Lysate ( ...
RFXAP Overexpression Lysate (Denat...
H00005994-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human RFXAP Prote ...
Recombinant Human RFXAP Protein
H00005994-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human RFXAP Prote ...
Recombinant Human RFXAP Protein
H00005994-P01
Species: Hu
Applications: WB, ELISA, PA
RFXAP Recombinant Protein Ant ...
RFXAP Recombinant Protein Antigen
NBP2-58217PEP
Species: Hu
Applications: AC
RNAi
RFXAP RNAi
RFXAP RNAi
H00005994-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The identification of transacting factors controlling major histocompatibility complex (MHC) class II gene transcription via the proximal enhancer of the promoter has been greatly facilitated by a genetic approach, namely, the analysis of cell lines that are characterized by regulatory defects abolishing transcription of these genes (Mach et al., 1996). Most of these MHC class II regulatory mutants are cell lines derived from patients suffering from MHC class II deficiency, also referred to as the bare lymphocyte syndrome type II, a rare autosomal recessive disorder characterized by the lack of constitutive and inducible MHC class II expression in all cell types and tissues. The genetic lesions responsible for this lack of expression lie not in MHC class II genes themselves, but in transacting regulatory genes required for their transcription (Mach et al., 1996). Durand et al. (1997) noted that at least 3 different complementation groups (groups A, B, and C) have been identified by means of somatic cell fusion experiments. the defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC class II promoters Durand et al. (1997) isolated a novel gene that encodes the 36-kD subunit of RFX. They called this subunit RFX-associated protein (RFXAP) because it is a subunit of the RFX complex and interacts with RFX5, yet it does not contain the characteristic RFX DNA-binding motif.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 5994
Alternate Names
  • RFX-associated protein
  • RFX DNA-binding complex 36 kDa subunit
  • regulatory factor X-associated protein

Research Areas for RFXAP

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
Stem Cell Markers
Transcription Factors and Regulators

PTMs for RFXAP

Learn more about PTMs related to RFXAP.

Phosphorylation
Methylation

Bioinformatics Tool for RFXAP

Discover related pathways, diseases and genes to RFXAP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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