PP14/Glycodelin Products

Description

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. A number of alternatively spliced transcript variants have been observed at this locus, but the full-length nature of only two, each encoding the same protein, has been determined.

Bioinformatics

Entrez	5047 Human
Uniprot	NP_002562 Human
Product By Gene ID	5047
Alternate Names	alpha uterine protein GdF GdS Glycodelin glycodelin-A glycodelin-F glycodelin-S MGC138509 MGC142288 PAEP PEP Placental protein 14 PP14 protein (placental protein 14) PP14 PP14GDPAEGGdA pregnancy-associated endometrial a Pregnancy-associated endometrial alpha-2 globulin pregnancy-associated endometrial alpha-2-globulin progestagen-associated endometrial protein (placental protein 14 progestagen-associated endometrial proteinPEG Progesterone-associated endometrial protein