PLUNC Products

Description

BPIFA1 (BPI fold-containing family A member 1), also named SPLUNC1, is a member of the BPI-fold (BPIF) containing/Plunc (palate, lung, and nasal epithelium clone) superfamily of putative innate defense molecules which are predominantly expressed in regions of the oral cavity, nasopharynx, and upper respiratory tract (1, 2). BPIF proteins exist as two subgroups, BPIFA (formally SPLUNCs) and BPIFB (formally LPLUNCs) (1, 3). BPIFA proteins have structural homology to the N‑terminal domain of BPI whereas BPIFB proteins have structural homology to both domains of BPI (2). The mature human BPIFA1 shares 68% amino acid (aa) identity with mouse and rat BIPFA1. BPIF proteins appear to exhibit distinct tissue and cell specific expression patterns with various family members, being localized to several glandular structures within the upper respiratory tract, nasopharyngeal regions and oral cavity where they are secreted from these tissues and are found in high levels in saliva and nasal and respiratory lining fluids (2). BPI proteins play a role in diverse functions, including neutralization of endotoxin (LPS) in septic shock patients, inhibition of endothelial cell growth, dendritic cell maturation, and function as an anti-angiogenic, chemoattractant or opsonization agent (2). BPIFA1 and BPIFB1 expression was increased in late-stage chronic obstructive pulmonary disease (COPD) patients, and elevated levels correlate with disease severity (4). BPIFs are also upregulated in cystic fibrosis (CF) lung disease and may play a role in the pathogenesis of the disease (5).

Bioinformatics

Uniprot	Q9NP55.1
Product By Gene ID	51297
Alternate Names	bA49G10.5 BPIFA1 ligand-binding protein RYA3 LPLUNC3 Lung-specific protein X LUNX LUNXNASG Nasopharyngeal carcinoma-related protein Palate lung and nasal epithelium clone protein palate, lung and nasal epithelium associated palate, lung and nasal epithelium carcinoma associated PLUNC protein Plunc Secretory protein in upper respiratory tracts SPLUNC1 SPLUNC1SPURT tracheal epithelium enriched protein Tracheal epithelium-enriched protein Von Ebner protein Hl