PLC-gamma 1 Products

Description

Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups (1). Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma 1 also has mitogenic activity upon growth-factor-dependent tyrosine phosphorylation; however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain (2). Also, results indicate a lipase-independent role of PLC-gamma in the physiological agonist-induced activation of Ca2+ entry (3).

Bioinformatics

Entrez	18803 Mouse 25738 Rat 5335 Human
Uniprot	NP_002651 Human P19174 Human
Product By Gene ID	5335
Alternate Names	EC 3.1.4.11 gamma 1 (formerly subtype 148) monophosphatidylinositol phosphodiesterase NCKAP3,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 phosphatidylinositol phospholipase C phosphoinositidase C phosphoinositide phospholipase C Phosphoinositide phospholipase C-gamma-1 phospholipase C, gamma 1 phospholipase C-148 Phospholipase C-gamma-1 Phospholipase C-II PLC11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 PLC148 PLC-148 PLC-gamma-1 PLC-II1-phosphatidyl-D-myo-inositol-4,5-bisphosphate triphosphoinositide phosphodiesterase

Research Areas for PLC-gamma 1

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Phospho-Specific
Signal Transduction