Species: Hu, Mu
Applications: WB, ChIP
Host: Rabbit Polyclonal
Species: Mu, Rt
Applications: WB, ELISA, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Description
Protein Kinase C gamma (PKC gamma) is an 80 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphotidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC gamma plays a key role in neuronal signal transduction and in regulating intercellular communication. The activation loop threonine (threonine 514 in PKC gamma) of conventional PKCs is phosphorylated by phosphoinositide-dependent kinase-1 (PDK1), which is necessary for its autophosphorylation on threonine 655 in the turn loop, and threonine 674 in the hydrophobic loop of the carboxy terminus, a critical step in generating a catalytically mature enzyme. The phosphorylation of the hydrophobic loop in the carboxyl terminus of PKCs is believed to be a key determinant in regulating PKC interaction with PDK1.
Bioinformatics
| Product By Gene ID |
5582 |
| Alternate Names |
- EC 2.7.11
- EC 2.7.11.13
- MGC57564
- PKC gamma
- PKCC
- PKCCSCA14
- PKCG
- PKC-gamma
- PKCGprotein kinase C gamma type
- PRKCG
- protein kinase C, gamma
- SCA14
|
